ارتباط پلی مورفیسم C3435T ژن MDR1 با پاسخ به درمان در بیماران سرطان پستان

Background and purpose: Breast cancer is the most common cancer in women. Most recently C3435T polymorphism of MDR1 gene is considered as one of the major causes of drug resistance in treatment of this disease. This study was conducted to investigate the relationship between C3435T MDR1 gene polymorphism and treatment response in breast cancer patients. Materials and methods: In this longitudinal study, blood samples were collected from all cases and gene polymorphism was performed by PCR-RFLP method. Then, all patients underwent chemotherapy and patient response to treatment was evaluated. They were divided into two categories according to clinical response to treatment and lack of treatment response. Results: This research included 152 women (mean age: 49.84±10.95 years) with breast cancer. The genotype found more frequently was CT (49.2%). Among the patients, 74.3% responded to treatments and in 25.7% there was no response to treatment. We found no significant differences between different genotypes in response to treatment (P=0.485). Conclusion: There was no direct relationship between the response of breast cancer to treatment and C3435T polymorphism of MDR1 gene.